In a large bowl combine cookies, butter, sugar, and salt and mix until butter is fully incorporated. Press into pie dish and set aside.
In a medium sauce pan over medium heat, combine sugar, corn syrup, vanilla, and water. Bring to a boil and cook, without stirring, until a candy thermometer reads 340°. Remove pan from heat and whisk in heavy cream and sour cream. Refrigerate until cool, 3-4 hours.
Place chocolate chips in a medium heat-proof bowl. In a small sauce pan over medium heat, heat cream until cream starts to simmer. Pour over chocolate and let sit 5 minutes before whisking until smooth.
Pour ganache over caramel and smooth. Sprinkle with flaky sea salt and refrigerate until set, about 1 hour. Serve.
Recipe by Cooking TV Recipes at https://cookingtv-channel.com/twix-pie/